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This roast beef panini sandwich layers deli roast beef, fontina cheese, roasted red peppers, spinach, and blue cheese mayo to make an easy, satisfying dinner in under half an hour.
A plate with two halves of a toasted roast beef panini layered with rare deli roast beef, roasted red peppers, fresh spinach, melted fontina, and creamy blue cheese mayo.

A roast beef panini is a quick way to turn everyday ingredients into a warm, satisfying dinner. Our version starts with rare deli roast beef and swaps out classic toppings like lettuce and tomato for layers of creamy melted fontina, roasted red peppers, fresh spinach, and a tangy blue cheese mayo spread.

Toasted until crisp on the outside and tender on the inside, this roast beef panini recipe is easy to make and ready in just 30 minutes – no fancy tools required.

Ingredient Notes and Substitutions

Here’s what you need to know about the key ingredients in this recipe. The complete list, including quantities, is in the printable recipe card below.

ROAST BEEF: Thin-sliced, rare, roast beef from the deli is the best choice for this panini. Boar’s Head brand makes several tasty top-round varieties – including a low-sodium version that you can season to taste if you want.

FONTINA CHEESE: We like fontina cheese for its buttery and creamy melting, but havarti and provolone are both good substitutes. Avoid aged or drier cheeses like cheddar as they won’t melt as nicely.

FRESH SPINACH: Spinach is a more nutritious and flavorful swap for lettuce on sandwiches. Baby spinach is more tender and consequently, our top choice for this purpose, but regular spinach is fine too. Just be sure to take a minute to pinch off the tough stems.

ROASTED RED PEPPERS: Jarred roasted red peppers add a sweet and savory quality to this sandwich along. Be sure to pat them dry first though so their packing liquid doesn’t make the rolls soggy.

BLUE CHEESE: We happen to like Gorgonzola cheese to bring that tangy flavor to our sandwich spread, but feel free to use any variety of blue cheese that you like.

ROLLS: Small torpedo/hoagie rolls with a slightly chewy crust are the best for this panini. They will crisp lightly on the outside and stay soft in the middle.

Prep Overview

How to Make Roast Beef Panini

Planning to make this recipe? Here’s a quick overview of how it’s done. Detailed, step-by-step instructions are in the printable recipe card below.

Combine the mayonnaise, garlic, and crumbled cheese in a small bowl until smooth and spreadable. Slice the rolls in and spread them with blue cheese mayo. Layer in the sandwich ingredients with the fontina on the top and bottom.

Heat a heavy pan over medium heat and brush the tops of the sandwiches with a bit of olive oil. Place them in the pan, oiled side down, weigh them down and cook until the cheese starts to melt and the rolls are golden. Flip, oil the other side, and cook until the second side is toasted.


Making Panini Without a Panini Maker

The overall goal when making panini is to fuse the flavors, toast the outside of the bread, and melt the cheese. This is how to accomplish this without a panini maker.

USE A HEAVY PAN: Cast iron grill pans or skillets, stainless steel, or carbon steel are all good choices. Avoid nonstick.

COAT THE OUTSIDE OF THE BREAD: Use a pastry brush to lightly coat the outside of your bread or rolls with oil or melted butter. Don’t apply a heavy coating as you would use for grilled cheese.

PREHEAT THE PAN: Preheating your pan over medium heat before adding the sandwiches gives the bread an instant sear for better a better crisp.

WEIGH DOWN THE SANDWICHES: Apply firm pressure to the sandwiches by weighing them down with a foil-covered brick, or a hand-held, cast iron grill press. (You can also use a pot lid that is smaller than the diameter of the pan you’re using and weigh it down with heavy cans.)

CHECK FOR DONENESS: Check your sandwiches after about 2 minutes. The idea is to get a crisp crust on the outside of your bread or rolls and melt the cheese inside the sandwich while keeping a tender texture on the interior of the bread.

More Delicious Sandwiches To Try

If you like this recipe, try our shortcut French Dip, also made with deli roast beef, and leveled up with caramelized onions, mushrooms, and creamy melted Muenster. For another option, try our Philly Cheesesteaks made with tender strip steak, sweet onions, and provolone. Or switch up those cheesesteak flavors with our Ribeye Steak Sandwich. It’s an elevated version loaded with mushrooms, spinach, and tangy blue cheese.

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A plate with two halves of a toasted roast beef panini layered with rare deli roast beef, roasted red peppers, fresh spinach, melted fontina, and creamy blue cheese mayo.
5 from 3 votes

Roast Beef Panini with Two Cheeses

This roast beef panini sandwich layers deli roast beef, fontina cheese, roasted red peppers, spinach, and blue cheese mayo to make an easy, satisfying dinner in under half an hour.
Prep: 10 minutes
Cook: 10 minutes
Total: 20 minutes
Servings: 4 servings

Ingredients

  • 4 torpedo/hoagie rolls, 6-inch
  • 8 slices fontina cheese
  • 3/4 lb rare deli roast beef, thinly sliced
  • 3 ounces fresh spinach leaves, stems removed
  • 12 ounces (1 jar) roasted red peppers, drained and patted dry with paper towels
  • Olive oil

For the Gorgonzola mayo

  • 1/3 cup mayonnaise
  • 1/2 teaspoon minced garlic
  • 1/2 cup crumbled blue cheese
  • Freshly ground black pepper
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Instructions 

  • Make the Gorgonzola mayo by combining the mayonnaise, garlic, and crumbled cheese in a small bowl until smooth and spreadable.
  • Slice the rolls in half lengthwise and spread a scant tablespoon of the mayo mixture on each half of the rolls.
  • Arrange 4 of the fontina slices (cut to fit) on the bottom half of each roll and arrange a layer of roasted red peppers on top.
  • Top with 3 to 4 slices (about 3 ounces) of roast beef, a layer of fresh spinach leaves, and the remaining fontina.
  • Place the other half of the roll on top and press down firmly.
  • Heat a grill pan over medium heat and brush the tops of the sandwiches lightly with olive oil.
  • Arrange two of the sandwiches, top side down, in the preheated pan and weigh them down with a sandwich press or other method (see notes). Cook until the cheese has melted and the roll is lightly toasted, 1-1/2 to 2 minutes.
  • Flip the sandwiches over, brush lightly with more olive oil, and weigh them down again. Cook for an additional 1-1/2 to 2 minutes.
  • Place finished sandwiches in a low oven (200°F) to keep warm while you repeat the process with the remaining two.
  • Cut each sandwich in half diagonally and serve immediately.

Nutrition

Calories: 692, Total Fat: 41g, Cholesterol: 126mg, Sodium: 1201mg, Carbohydrates: 30g, Fiber: 4g, Sugar: 5g, Protein: 43g

Nutrition information is automatically calculated, so should only be used as an approximation.

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Lynne Webb and Erika Pitera, creators of MyGourmetConnection in the kitchen, working on a soup recipe for the website.

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We’re Lynne and Erika, a mother-daughter duo passionate about creating recipes that bring flavor and variety to your kitchen in a simple, approachable way.

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4 Comments

  1. Love your site…the recipes are ones that ordinary cooks can do with not much trouble. Such a variety that we can choose from and have easy to get ingredients.

    Thanks so much for making cooking fun.

    1. Hi Gail,
      Thanks so much for your nice comment. It’s always nice to hear that we’re on the right track with our recipes.